Morpholine → 2-Methyl-4-chloro-6-morpholino-pyridine

HRID 252983

反応式

HRID 252983 の反応式
[CH3:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[C:4](Cl)[N:3]=1.[NH:10]1[CH2:15][CH2:14][O:13][CH2:12][CH2:11]1>ClCCl>[CH3:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[C:4]([N:10]2[CH2:15][CH2:14][O:13][CH2:12][CH2:11]2)[N:3]=1

参加物

4

反応物 2

HCID 8083MorpholineHCID 119590832,4-Dichloro-6-methylpyridine

生成物 1

HCID 575505222-Methyl-4-chloro-6-morpholino-pyridine

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

反応条件

温度
-78 °C

実験手順

2-Methyl-4,6-dichloropyridine (256 mmol) is dissolved in dichloromethane (200 mL) and chilled to −78° C. in an inert atmosphere. Morpholine (550 mol) dissolved in dichloromethane (100 mL) is added slowly. The reaction is allowed to warm to room temperature while stirring overnight. The organic layer is washed with saturated ammonium chloride (2×100 mL), dried with sodium sulfate, and evaporated to give 2-methyl-4-chloro-6-morpholino-pyridine.

後処理

  1. additionis added slowly
  2. temperatureto warm to room temperature
  3. washThe organic layer is washed with saturated ammonium chloride (2×100 mL)
  4. dry with materialdried with sodium sulfate
  5. customevaporated

出典と根拠

ORDレコード
ord-f6527866ffd046748a51042fcc0e358d
出典データセット
uspto-grants-2011_01
特許番号
US07872005B2

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