2-Formyl-5-(2-methylphenyl)phenol → 2-hydroxy-4-phenylbenzaldehyde

HRID 25315ノート

反応式

HRID 25315 の反応式
[OH:1][C:2]1[CH:9]=[C:8]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=2C)[CH:7]=[CH:6][C:3]=1[CH:4]=[O:5].Cl.Cl.NC1C2C(=CC=CC=2O)C(S(O)(=O)=O)=CC=1N.S(=O)(O)[O-].[Na+]>CCO.O>[OH:1][C:2]1[CH:9]=[C:8]([C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=2)[CH:7]=[CH:6][C:3]=1[CH:4]=[O:5]

参加物

6

反応物 3

HCID 225667242-Formyl-5-(2-methylphenyl)phenolHCID 23665763Sodium BisulfiteHCID 865878481,2-Diamino-8-hydroxy-naphthalene-4-sulfonic acid dihydrochloride

生成物 1

HCID 115792992-hydroxy-4-phenylbenzaldehyde収率 104.5%

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 962Water溶媒

反応条件

温度
60 °C

実験手順

To an agitated solution of 2-hydroxy-4-(2′-methylphenyl)benzaldehyde (0.030 g, 0.14 mmol) in EtOH (0.80 mL) was added 1,2-diamino-8-hydroxy-naphthalene-4-sulfonic acid dihydrochloride (0.033 g, 0.10 mmol) and sodium bisulfite (0.03 g) in water (0.20 mL). The solution was heated to 60° C. and agitated over 18 hours. The solution was cooled to room temperature, the tan precipitate was isolated by filtration and washed with water and ethyl acetate to provide the title compound (0.029 g, 60%) MS(ES) m/z 445 [M−H].

後処理

  1. temperatureThe solution was cooled to room temperature
  2. customthe tan precipitate was isolated by filtration
  3. washwashed with water and ethyl acetate

出典と根拠

ORDレコード
ord-e1675aaf8d5e4b36997b0c8196f52094
出典データセット
uspto-grants-2005_02
特許番号
US06858630B2

反応ノート

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