Potassium Hydroxide → 1,3-Diphenyl-2-propyn-1-one

HRID 253196

反応式

HRID 253196 の反応式
[OH-].[K+].[CH:3]1[CH:8]=[CH:7][C:6](/[CH:9]=[C:10](\Br)/[C:11]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[O:12])=[CH:5][CH:4]=1>O.O.CC(C)=O>[CH:3]1[CH:8]=[CH:7][C:6]([C:9]#[C:10][C:11]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[O:12])=[CH:5][CH:4]=1

参加物

5

反応物 2

HCID 14797Potassium HydroxideHCID 5383396alpha-Bromochalcone

生成物 1

HCID 976371,3-Diphenyl-2-propyn-1-one

試薬・触媒・溶媒 2

HCID 962Water溶媒2 回HCID 18366337Propan-2-one--water (1/1)溶媒

実験手順

Potassium hydroxide (3.48 mmol), dissolved in water (0.87 M (4.0 ml)), is added over about 30 minutes to a refluxing solution of the alpha-bromochalcone (3.48 mmol) in 0.35 M of 1:1 water/acetone (5 ml each). After 20 minutes of further refluxing, the solution is cooled and diluted with water. The water is extracted with ether, which is dried with MgSO4 and evaporated. Chromatography on silica gel yielded 1,3-diphenylpropynone and its derivatives.

後処理

  1. temperaturethe solution is cooled
  2. extractionThe water is extracted with ether, which
  3. dry with materialis dried with MgSO4
  4. customevaporated

出典と根拠

ORDレコード
ord-4ba327e74c5243feaac8ef51b5912f6b
出典データセット
uspto-grants-2011_01
特許番号
US07872029B2

関連ノート

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