2,6-Dimethylbenzaldehyde → 4-Iodomethyl-5-ethyl-2-(2,6-dimethylphenyl)oxazole

反応式

[I:1][CH2:2][C:3]1[N:4]=C(C2C=CC(C)=CC=2)O[C:7]=1[C:8]1C=CC=C[CH:9]=1.C(C(=O)C(=NO)C)C.[CH3:29][C:30]1[CH:37]=[CH:36][CH:35]=[C:34]([CH3:38])[C:31]=1[CH:32]=[O:33]>>[I:1][CH2:2][C:3]1[N:4]=[C:32]([C:31]2[C:34]([CH3:38])=[CH:35][CH:36]=[CH:37][C:30]=2[CH3:29])[O:33][C:7]=1[CH2:8][CH3:9]

参加物

反応物 3

HCID 5838412,6-Dimethylbenzaldehyde

HCID 67974532,3-Pentanedione, 2-oxime

HCID 574345044-Iodomethyl-5-phenyl-2-p-tolyloxazole

生成物 1

HCID 574345084-Iodomethyl-5-ethyl-2-(2,6-dimethylphenyl)oxazole

実験手順

Analogously to the building block synthesis of 4-iodomethyl-5-phenyl-2-p-tolyloxazole, 1-ethyl-1,2-propanedione-2-oxime and 2,6-dimethylbenzaldehyde gave 4-iodomethyl-5-ethyl-2-(2,6-dimethylphenyl)oxazole.

出典と根拠

ORDレコード: ord-cbd07d16009b4bda912ffea744f2a48a
出典データセット: uspto-grants-2011_01
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07872034B2

反応ノート

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