3-(Trifluoromethyl)benzaldehyde → 2-(3-Trifluoromethylphenyl)4-iodomethyl-5-methyloxazole

反応式

[I:1][CH2:2][C:3]1[N:4]=[C:5]([C:14]2[CH:19]=[CH:18][C:17](C)=[CH:16][CH:15]=2)[O:6][C:7]=1[C:8]1C=CC=CC=1.C/C(/C(C)=O)=N\O.[F:28][C:29]([F:39])([F:38])C1C=C(C=CC=1)C=O>>[I:1][CH2:2][C:3]1[N:4]=[C:5]([C:14]2[CH:15]=[CH:16][CH:17]=[C:18]([C:29]([F:39])([F:38])[F:28])[CH:19]=2)[O:6][C:7]=1[CH3:8]

参加物

反応物 3

HCID 679903-(Trifluoromethyl)benzaldehyde

HCID 64096332,3-Butanedione monoxime

HCID 574345044-Iodomethyl-5-phenyl-2-p-tolyloxazole

生成物 1

HCID 224936812-(3-Trifluoromethylphenyl)4-iodomethyl-5-methyloxazole

実験手順

Analogously to the building block synthesis of 4-iodomethyl-5-phenyl-2-p-tolyloxazole, diacetylmonoxime and 3-trifluoromethylbenzaldehyde gave 4-iodomethyl-5-methyl-2-(3-trifluoromethylphenyl)oxazole.

出典と根拠

ORDレコード: ord-b9be624fc4494ee897142306baafa463
出典データセット: uspto-grants-2011_01
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07872034B2

反応ノート

読み込み中…