関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Kojic Acid | HCID 3840 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | 1-(Bromomethyl)-4-chlorobenzene | HCID 69329 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 5-(4-Chloro-benzyloxy)-2-hydroxymethyl-pyran-4-one | HCID 58086834 | — |
反応手順
Kojic acid (70, 5.00 g, 35.2 mmol) and 4-chlorobenzyl bromide (22, 7.95 g, 38.7 mmol) were suspended in methanol (40 mL) in an 80 mL sealed tube. Sodium hydroxide in water (12 M, 2.93 ml) was added, The reaction was heated at 80° C. overnight. The resulting suspension was concentrated. Water was added and the mixture was filtered and washed with water to provide a brown solid. Washing with minimal methanol on the filter removed the brown color. A white solid (71, 7.58 g, 80%) was isolated. 1H-NMR was consistent with the desired compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07872018B2 |
|---|
| 出典データセット | uspto-grants-2011_01 |
|---|
| ORD ID | ord-f4a65107e2984098a7215a47509e8780 |
|---|
| 出典メモ | uspto-grants-2011_01 |
|---|
