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Glycine ethyl ester → N-Oleoylglycine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Glycine ethyl ester | HCID 12176 | — |
| 反応物 | 1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide | HCID 15908 | — |
| 反応物 | Glycinamide | HCID 69020 | — |
| 反応物 | Oleic Acid | HCID 445639 | — |
| 反応物 | Oleoyl Sarcosine | HCID 6912870 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | N-Oleoylglycine | HCID 6436908 | — |
反応手順
N-Oleoyl glycine (FIG. 7) was prepared by coupling glycine ethyl ester to oleic acid with EDCI (Cravatt et al. (1996) J. Am. Chem. Soc. 118, 580-590; Patterson et al. (1996) J. Am. Chem. Soc. 118, 5938-5945) followed by sequential transformation to the carboxylic acid (LiOH) and glycinamide (EDCI, NH4OH;). N-Oleoyl sarcosine was purchased (Pfaltz and Bauer) and converted to its ethyl ester by coupling with EtOH (DCC).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06858649B1 |
| 出典データセット | uspto-grants-2005_02 |
| ORD ID | ord-f5ac59a7fb8540c8a6d0e1f04c8cecc0 |
| 出典メモ | uspto-grants-2005_02 |