2-(6-bromo-1H-pyrrolo[2,3-b]pyridin-1-yl)(phenyl)methanone → 6-Bromo-7-azaindole
反応式
[Br:1][C:2]1[N:7]=[C:6]2[N:8](C3C=CC=CC=3C=O)[CH:9]=[CH:10][C:5]2=[CH:4][CH:3]=1>O1CCOCC1.[OH-].[K+]>[Br:1][C:2]1[N:7]=[C:6]2[NH:8][CH:9]=[CH:10][C:5]2=[CH:4][CH:3]=1参加物
4
実験手順
(6-bromo-1H-pyrrolo[2,3-b]pyridin-1-yl)(phenyl)methanone 155 was dissolved in 20 mL of dioxane and 20 mL of 2M KOH (aq). This was stirred at ambient temperature until analysis indicated all of the starting material had been consumed (2 to 4 hours). The reaction was diluted with 50 mL of ethyl acetate and washed with 2×25 mL of NaHCO3 (aq. satd.) and 25 mL of brine. The organic layer was dried with sodium sulfate, evaporated and purified by column chromatography. Combined steps 2 and 3 gave approximately 65% overall yield.
後処理
- customhad been consumed (2 to 4 hours)
- additionThe reaction was diluted with 50 mL of ethyl acetate
- washwashed with 2×25 mL of NaHCO3 (aq. satd.) and 25 mL of brine
- dry with materialThe organic layer was dried with sodium sulfate
- customevaporated
- custompurified by column chromatography
- customgave approximately 65% overall yield
出典と根拠
- ORDレコード
- ord-713df9f7ab6c43edb73d1bd9ca0686f7
- 出典データセット
- uspto-grants-2011_01
- 特許番号
- US07872018B2
反応ノート
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