関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Chloroacetic Acid | HCID 300 | — |
| 反応物 | N-Methyl-o-phenylenediamine | HCID 78498 | — |
| 溶媒 | Hydrochloric Acid | HCID 313 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | Sodium Bicarbonate | HCID 516892 | — |
| 生成物 | 2-(Chloromethyl)-1-methylbenzimidazole | HCID 248044 | 87.8% |
反応手順
N-methyl-phenylenediamine (1 g, 8.2 mmol) and chloroacetic acid (0.9 g, 9.4 mol) were dissolved in 5 N aqueous hydrochloric acid (10 mL) and stirred at 55° C. overnight. The reaction mixture was then diluted with water and basified with solid sodium bicarbonate to give a precipitate which was filtered, washed with water and dried to provide the desired compound (1.3 g, 87%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07872018B2 |
|---|
| 出典データセット | uspto-grants-2011_01 |
|---|
| ORD ID | ord-ba330bcfa33e419daff6496203bb19c7 |
|---|
| 出典メモ | uspto-grants-2011_01 |
|---|
