化工社化工社 化学情報印刷レポート · 研究参考用
Sodium Hydroxide → Sertraline
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | (1S,4S)-4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalen-1-amine;2-hydroxy-2-phenylacetate | HCID 131718189 | — |
| 溶媒 | Ethyl Acetate | HCID 8857 | — |
| 生成物 | Sertraline | HCID 68617 | — |
反応手順
Sertraline base for use in the processes of the present invention may be produced by dissolving sertraline mandelate in ethyl acetate followed by neutralization of the sertraline mandelate with aqueous sodium hydroxide. The organic phase is separated from the aqueous phase and dried using magnesium sulfate. The solvent is removed under reduced pressure to produce sertraline base as an oil. Methods for making sertraline base are set forth in U.S. Pat. Nos. 4,536,518 and 5,248,699, the contents of which are incorporated herein by reference.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06858652B2 |
| 出典データセット | uspto-grants-2005_02 |
| ORD ID | ord-15512c7e7af3433e81fa4f962cc8560c |
| 出典メモ | uspto-grants-2005_02 |