化工社化工社 化学情報印刷レポート · 研究参考用
HRID 253525作成日：2026年10月27日
Ethanol → 5-Amino-1-(2-chloro-6-ethoxy-4-trifluoromethylphenyl)-3-cyano-4-trifluoromethylthiopyrazole
https://huagongshe.com/reaction/253525
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Ethanol | HCID 702 | — |
| 反応物 | Fipronil sulfide | HCID 9953940 | — |
| 反応物 | Ethylacetate heptane | HCID 21899848 | — |
| 反応物 | Sodium t-butoxide | HCID 23676156 | — |
| 触媒 | copper(I) bromide | HCID 24593 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 5-Amino-1-(2-chloro-6-ethoxy-4-trifluoromethylphenyl)-3-cyano-4-trifluoromethylthiopyrazole | HCID 11419008 | — |
反応手順
To a mixture of 5-amino-1-(2,6-dichloro-4-trifluoromethylphenyl)-3-cyano-4-trifluoromethylthiopyrazole (4.5 g, 10.7 mmol) and ethanol (0.73 g, 16.0 mmol) in N,N-dimethylformamide (25 ml), was added sodium tert-butoxide (1.54 g, 16.0 mmol) and copper(I)bromide (0.08 g, 0.5 mmol). The mixture was heated at 90° C. for 7 hours under nitrogen. After extractive workup (heptane-ethyl acetate, water) and column chromatography the title product was obtained (2.17 g), mp 166° C., 1H-NMR: 1.34 (3H), 4.14 (2H), 4.35 (2H), 7.20 and 7.45; 19F-NMR: −45.2, −63.9.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US07872038B2 |
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| 出典データセット | uspto-grants-2011_01 |
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| ORD ID | ord-25d93cffb5214c8f898fd5d5e569c14d |
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| 出典メモ | uspto-grants-2011_01 |
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