Hydrochloric Acid → Hydrochloric Acid

反応式

[CH3:1][O:2][CH2:3][CH2:4][CH2:5][O:6][C@@H:7]([C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)[C@@H:8]1[CH2:13][CH2:12][CH2:11][N:10](C(OC(C)(C)C)=O)[CH2:9]1.[ClH:27]>O1CCOCC1>[CH3:1][O:2][CH2:3][CH2:4][CH2:5][O:6][C@@H:7]([C:21]1[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=1)[C@@H:8]1[CH2:13][CH2:12][CH2:11][NH:10][CH2:9]1.[ClH:27]

参加物

実験手順

(R)-tert-Butyl 3-((R)-(3-methoxypropoxy)(phenyl)methyl)piperidine-1-carboxylate (27 mg, 0.074 mmol) was mixed with 4M HCl in 1,4-dioxane (3 mL) and stirred for 30 min at rt. LC-MS showed complete removal of the Boc protecting group. The mixture was concentrated to afford (R)-3-((R)-(3-methoxypropoxy)(phenyl)methyl)piperidine as its HCl salt. This material was used without purification.