Methylamine ethanol → tert-butyl (2S,3R)-3-hydroxy-4-(methylamino)-1-(tetrahydro-2H-pyran-4-yl)butan-2-ylcarbamate
反応式
[C:1]([O:5][C:6](=[O:19])[NH:7][CH:8]([CH:16]1[CH2:18][O:17]1)[CH2:9][CH:10]1[CH2:15][CH2:14][O:13][CH2:12][CH2:11]1)([CH3:4])([CH3:3])[CH3:2].[CH3:20][NH2:21].CCO>>[OH:17][C@H:16]([CH2:18][NH:21][CH3:20])[C@@H:8]([NH:7][C:6](=[O:19])[O:5][C:1]([CH3:4])([CH3:3])[CH3:2])[CH2:9][CH:10]1[CH2:15][CH2:14][O:13][CH2:12][CH2:11]1参加物
3
反応条件
- 温度
- 35 °C
実験手順
A 250 mL flask was charged with [1-oxiranyl-2-(tetrahydro-pyran-4-yl)-ethyl]-carbamic acid tert-butyl ester (150 mg, 0.55 mmol) dissolved in MeNH2/EtOH solution and stirred overnight at 30-40° C. Then the mixture was concentrated and used directly in the next step.
後処理
- concentrationThen the mixture was concentrated