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2-Methanesulfonylbenzene-1-sulfonyl chloride → N-(3-cyano-1H-indazol-5-yl)-2-methylsulfonylbenzenesulfonamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Methanesulfonylbenzene-1-sulfonyl chloride | HCID 2735178 | — |
| 反応物 | 5-Amino-1H-indazole-3-carbonitrile | HCID 22567303 | — |
| 溶媒 | Pyridine | HCID 1049 | — |
| 生成物 | N-(3-cyano-1H-indazol-5-yl)-2-methylsulfonylbenzenesulfonamide | HCID 10045063 | 11.5% |
反応手順
N-(3-Cyano-1H-indazol-5-yl)-2-methylsulfonylbenzenesulfonamide can be obtained as described in Example 2 from 0.55 g of 3-cyano-5-amino-1H-indazole, 10 ml of pyridine and 0.88 g of 2-methylsulfonylbenzenesulfonyl chloride. 0.15 g of N-(3-cyano-1H-indazol-5-yl)-2-methylsulfonylbenzenesulfonamide is thus obtained in the form of a yellow powder melting at 272° C. (analysis C15H12N4O4S2.0.85H2O, % calculated C, 47.87; H, 3.21; N, 14.88; S, 17.04. % found C, 47.88; H, 3.01; N, 14.75; S, 17.45).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06858638B2 |
| 出典データセット | uspto-grants-2005_02 |
| ORD ID | ord-f83a3feddd8547ec88d94ae942a358e4 |
| 出典メモ | uspto-grants-2005_02 |