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Ammonium formate → tert-Butyl 5-amino-3-methyl-1H-indazole-1-carboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ammonium formate | HCID 2723923 | — |
| 反応物 | tert-Butyl 3-methyl-5-nitro-1H-indazole-1-carboxylate | HCID 22567205 | — |
| 触媒 | Palladium | HCID 23938 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | tert-Butyl 5-amino-3-methyl-1H-indazole-1-carboxylate | HCID 59276571 | 89% |
反応手順
5-Amino-N-tert-butoxycarbonyl-3-methyl-1H-indazole can be obtained as described in Example 6 from 3.4 g of N-tert-butoxycarbonyl-3-methyl-5-nitro-1H-indazole, 50 ml of methanol, 0.61 g of 10% palladium-on-charcoal and 3.53 g of ammonium formate. 2.7 g of 5-amino-N-tert-butoxycarbonyl-3-methyl-1H-indazole are thus obtained in the form of a cream solid melting at 185° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06858638B2 |
| 出典データセット | uspto-grants-2005_02 |
| ORD ID | ord-fcdd43b1809b47dfab16fdca94887db9 |
| 出典メモ | uspto-grants-2005_02 |