Ammonium formate → tert-Butyl 5-amino-3-methyl-1H-indazole-1-carboxylate

HRID 25366

反応式

HRID 25366 の反応式
[C:1]([O:5][C:6]([N:8]1[C:16]2[C:11](=[CH:12][C:13]([N+:17]([O-])=O)=[CH:14][CH:15]=2)[C:10]([CH3:20])=[N:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].C([O-])=O.[NH4+]>[Pd].CO>[NH2:17][C:13]1[CH:12]=[C:11]2[C:16](=[CH:15][CH:14]=1)[N:8]([C:6]([O:5][C:1]([CH3:3])([CH3:2])[CH3:4])=[O:7])[N:9]=[C:10]2[CH3:20]

参加物

5

反応物 2

HCID 2723923Ammonium formateHCID 22567205tert-Butyl 3-methyl-5-nitro-1H-indazole-1-carboxylate

生成物 1

HCID 59276571tert-Butyl 5-amino-3-methyl-1H-indazole-1-carboxylate収率 89%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

5-Amino-N-tert-butoxycarbonyl-3-methyl-1H-indazole can be obtained as described in Example 6 from 3.4 g of N-tert-butoxycarbonyl-3-methyl-5-nitro-1H-indazole, 50 ml of methanol, 0.61 g of 10% palladium-on-charcoal and 3.53 g of ammonium formate. 2.7 g of 5-amino-N-tert-butoxycarbonyl-3-methyl-1H-indazole are thus obtained in the form of a cream solid melting at 185° C.

出典と根拠

ORDレコード
ord-fcdd43b1809b47dfab16fdca94887db9
出典データセット
uspto-grants-2005_02
特許番号
US06858638B2

関連ノート

読み込み中…