Gamma-Aminobutyric Acid → Alendronic Acid

温度

92.5 °C

4-Aminobutyric acid (50 gm), phosphorous acid (140 gm) and n-octane (1000 mL) was taken in a four necked round bottom flask fitted with an addition funnel, mechanical stirrer, condenser and thermometer pocket and allowed to stir at 90-95° C. Phosphorus trichloride (240 gm) was then added to the reaction mixture and allowed to heat at 90-95° C. The reaction mixture was cooled and distilled water (500 mL) was added to it. The reaction mixture was further heated to 90-95° C. It was then cooled and ethanol (1000 mL) was added to it. The solution was further cooled to 0-5° C. and stirred for 4-5 hrs. The precipitated solid was filtered and washed with ethanol and dried under vacuum to yield 52.0 gm product.

1. customfitted with an addition funnel, mechanical stirrer, condenser
2. temperatureto heat at 90-95° C
3. temperatureThe reaction mixture was cooled
4. distillationdistilled water (500 mL)
5. additionwas added to it
6. temperatureThe reaction mixture was further heated to 90-95° C
7. temperatureIt was then cooled
8. additionethanol (1000 mL) was added to it
9. temperatureThe solution was further cooled to 0-5° C.
10. stirringstirred for 4-5 hrs
11. filtrationThe precipitated solid was filtered
12. washwashed with ethanol
13. customdried under vacuum

ORDレコード

ord-3e98a1a764f74a5698540f31dfd2bd9c

出典データセット

uspto-grants-2011_01

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US07872144B2