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Benzenesulfonyl chloride, 3,4-dichloro- → N-(N-tert-butoxycarbonyl-3-methyl-1H-indazol-5-yl)-3,4-dichlorobenzenesulfonamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Benzenesulfonyl chloride, 3,4-dichloro- | HCID 7383 | — |
| 反応物 | Tetrahydrofuran | HCID 8028 | — |
| 反応物 | tert-Butyl 5-amino-3-methyl-1H-indazole-1-carboxylate | HCID 59276571 | — |
| 溶媒 | Triethylamine | HCID 8471 | — |
| 生成物 | N-(N-tert-butoxycarbonyl-3-methyl-1H-indazol-5-yl)-3,4-dichlorobenzenesulfonamide | HCID 22567170 | 43.4% |
反応手順
N-(N-tert-Butoxycarbonyl-3-methyl-1H-indazol-5-yl)-3,4-dichlorobenzenesulfonamide can be obtained as described in Example 1 from 1 g of 5-amino-N-tert-butoxycarbonyl-3-methyl-1H-indazole, 50 ml of tetrahydrofuran, 1.15 ml of triethylamine and 1.1 g of 3,4-dichlorobenzenesulfonyl chloride. 0.8 g of N-(N-tert-butoxycarbonyl-3-methyl-1H-indazol-5-yl)-3,4-dichlorobenzenesulfonamide is thus obtained in the form of a white solid melting at 171° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06858638B2 |
| 出典データセット | uspto-grants-2005_02 |
| ORD ID | ord-4989f77d96a64fd1bef6fc477d954100 |
| 出典メモ | uspto-grants-2005_02 |