3,6-Dimethylpicolinonitrile → (3,6-Dimethylpyridin-2-yl)methanamine
反応式
[CH3:1][C:2]1[C:3]([C:9]#[N:10])=[N:4][C:5]([CH3:8])=[CH:6][CH:7]=1>CCO.[Ni]>[CH3:1][C:2]1[C:3]([CH2:9][NH2:10])=[N:4][C:5]([CH3:8])=[CH:6][CH:7]=1参加物
4
実験手順
A solution of 3,6-dimethylpyridine-2-carbonitrile (264 mg, 2.00 mmol) in EtOH (10 mL) was treated with Raney-Ni (approximately 100 mg) and stirred under an atmosphere of hydrogen for 4 h at room temperature. The mixture was filtered through Celite and concentrated in vacuo to give the title compound (270 mg, 99%) as a yellow oil; NMR δH (400 MHz, CDCl3) 2.31 (3H, s), 2.51 (3H, s), 4.17 (2H, s), 7.00 (1H, d, J 7.5 Hz) and 7.37 (1H, d, J 7.5 Hz); M/Z 137 (M+H)+.
後処理
- filtrationThe mixture was filtered through Celite
- concentrationconcentrated in vacuo
出典と根拠
- ORDレコード
- ord-adf20956633e444db0ed7d2b3ce78923
- 出典データセット
- uspto-grants-2011_01
- 特許番号
- US07875600B2
反応ノート
読み込み中…