Hydrochloric Acid → HCID 178482379、化合物
反応式
C(OC(=O)[NH:7][C@H:8]1[CH2:13][CH2:12][C@H:11]([CH2:14][CH2:15][N:16]2[CH2:21][CH2:20][N:19]([C:22]3[C:27]([Cl:28])=[C:26]([Cl:29])[N:25]=[C:24]([NH:30][CH3:31])[N:23]=3)[CH2:18][CH2:17]2)[CH2:10][CH2:9]1)(C)(C)C.[ClH:33]>C(OC(=O)C)C>[ClH:28].[ClH:33].[ClH:28].[NH2:7][C@H:8]1[CH2:13][CH2:12][C@H:11]([CH2:14][CH2:15][N:16]2[CH2:17][CH2:18][N:19]([C:22]3[C:27]([Cl:28])=[C:26]([Cl:29])[N:25]=[C:24]([NH:30][CH3:31])[N:23]=3)[CH2:20][CH2:21]2)[CH2:10][CH2:9]1参加物
4
実験手順
4.88 g (10 mmol) trans-(4-{2-[4-(5,6-dichloro-2-methylamino-pyrimidin-4-yl)-piperazin-1-yl]-ethyl}-cyclohexyl)-carbamic acid tert-butyl ester was deprotected at 10° C. using 100 ml ethylacetate saturated with gaseous hydrochloric acid. After 4 hours the precipitate was filtered giving the title compound (4.9 g, 99%), melting at 325-326° C.