Methylamine → N-methyl-5-nitropyridin-2-amine
反応式
[CH3:1][NH2:2].Cl[C:4]1[CH:9]=[CH:8][C:7]([N+:10]([O-:12])=[O:11])=[CH:6][N:5]=1>ClCCl>[CH3:1][NH:2][C:4]1[CH:9]=[CH:8][C:7]([N+:10]([O-:12])=[O:11])=[CH:6][N:5]=1参加物
4
実験手順
Methylamine gas was bubbled through a stirred solution of 2-chloro-5-nitropyridine (4 g, 25.2 mmol) in dichloromethane (60 mL), at room temperature, until saturation had occurred. The resulting yellow precipitate was then filtered off, washed with dichloromethane and dried under vacuum to afford the title compound as a yellow solid in 80% yield, 3.07 g.
後処理
- filtrationThe resulting yellow precipitate was then filtered off
- washwashed with dichloromethane
- customdried under vacuum
出典と根拠
- ORDレコード
- ord-54ea1faa8e804387b6c55cbb2b3de74e
- 出典データセット
- uspto-grants-2011_01
- 特許番号
- US07875615B2
反応ノート
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