Ethylenediamine → 2-(2-cyclopropyl-6-methyl-benzyl)-4,5-dihydro-1H-imidazole

反応式

[CH:1]1([C:4]2[CH:9]=[CH:8][CH:7]=[C:6]([CH3:10])[C:5]=2[CH:11]=[C:12](Br)Br)[CH2:3][CH2:2]1.[CH2:15]([NH2:18])[CH2:16][NH2:17]>>[CH:1]1([C:4]2[CH:9]=[CH:8][CH:7]=[C:6]([CH3:10])[C:5]=2[CH2:11][C:12]2[NH:17][CH2:16][CH2:15][N:18]=2)[CH2:3][CH2:2]1

参加物

反応物 2

HCID 3301Ethylenediamine

HCID 589517431-Cyclopropyl-2-(2,2-dibromo-vinyl)-3-methyl-benzene

生成物 1

HCID 589518352-(2-cyclopropyl-6-methyl-benzyl)-4,5-dihydro-1H-imidazole

実験手順

2-(2-cyclopropyl-6-methyl-benzyl)-4,5-dihydro-1H-imidazole was prepared from 1-cyclopropyl-2-(2,2-dibromo-vinyl)-3-methyl-benzene and ethylenediamine in analogy to Example 1e): yellow crystals; MS (ISP): 215.3 ([M+H]+, 100%).

出典と根拠

ORDレコード: ord-037b38b7d0fb4e96950d4abecfec6a3a
出典データセット: uspto-grants-2011_01
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07875645B2

反応ノート

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