化工社化工社 化学情報印刷レポート · 研究参考用
HRID 254654作成日：2026年10月26日
4-Bromo-1,1,1-trifluorobutane → 5-tert-butyl-3-(4,4,4-trifluorobutyl)thiazol-2(3H)-imine hydrobromide
https://huagongshe.com/reaction/254654
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 4-Bromo-1,1,1-trifluorobutane | HCID 521006 | — |
| 反応物 | 5-tert-Butyl-1,3-thiazol-2-amine | HCID 676485 | — |
| 生成物 | 5-tert-butyl-3-(4,4,4-trifluorobutyl)thiazol-2(3H)-imine hydrobromide | HCID 66852123 | 63% |
反応手順
A mixture of the product of Example 74A (0.25 g, 1.6 mmol) and 1-bromo-4,4,4-trifluorobutane (336 mg, 1.8 mmol) was warmed to 85° C. and was stirred for 16 hours. The mixture was cooled to ambient temperature and the title compound (0.35 g, 63% yield) was isolated via filtration. MS (DCI/NH3) m/z 267 (M+H)+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US07875640B2 |
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| 出典データセット | uspto-grants-2011_01 |
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| ORD ID | ord-6bd9a4d7479a43eeabafee4851dea8d0 |
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| 出典メモ | uspto-grants-2011_01 |
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