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Glutaric anhydride → Succinimide glutarate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Glutaric anhydride | HCID 7940 | — |
| 反応物 | Dicyclohexylcarbodiimide | HCID 10868 | — |
| 反応物 | N-Hydroxysuccinimide | HCID 80170 | — |
| 反応物 | Glutarate(2-) | HCID 4418048 | — |
| 生成物 | Succinimide glutarate | HCID 86592295 | — |
反応手順
As depicted in above Scheme 2, 6-arm PEG (1) synthesized in the Scheme 1 is reacted with glutarate reagents, e.g., glutaric anhydride to synthesize 6-arm PEG-glutatic acid (6-arm PEG-GA) (2). The compound (2) was reacted with N-hydroxy succinimide (NHS) and N, N′-dicyclohexylcarbodiimide (DCC) to produce 6-arm PEG-succinimide glutarate (6-arm PEG-SG) (3).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06858736B2 |
| 出典データセット | uspto-grants-2005_02 |
| ORD ID | ord-21362a60159840c9abdcc13b32c63fc9 |
| 出典メモ | uspto-grants-2005_02 |