化工社化工社 化学情報印刷レポート · 研究参考用
Hydrogen Peroxide → (4R,4aS,12bS)-4a-hydroxy-9-methoxy-3-methyl-2,4,7a,13-tetrahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrogen Peroxide | HCID 784 | — |
| 反応物 | Peracetic Acid | HCID 6585 | — |
| 反応物 | Oxycodone | HCID 5284603 | — |
| 反応物 | Codeinone | HCID 5459910 | — |
| 反応物 | (4R,7aR,12bS)-7,9-dimethoxy-3-methyl-2,4,7a,13-tetrahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline;2,3,4-trihydroxy-4-oxobutanoate | HCID 131728625 | — |
| 溶媒 | Formic Acid | HCID 284 | — |
| 溶媒 | Isopropanol | HCID 3776 | — |
| 生成物 | (4R,4aS,12bS)-4a-hydroxy-9-methoxy-3-methyl-2,4,7a,13-tetrahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one | HCID 5359420 | — |
反応手順
Oxycodone has also been prepared from thebaine bitartrate and codeinone ethyldienol ether by oxidation with hydrogen peroxide in formic acid and isopropanol, followed by catalytic hydrogenation5. Oxycodone has also been prepared by the oxidation with peracetic acid of codeinone dienol silylether in organic solvents to give 14-hydroxycodeinone, followed by catalytic hydrogenation in acetic acid solution15.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07875719B2 |
| 出典データセット | uspto-grants-2011_01 |
| ORD ID | ord-4a9bcdf3242041dfa8552b1c331e322b |
| 出典メモ | uspto-grants-2011_01 |