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HRID 25489作成日：2026年10月25日
3,5-Dichlorophenyl isothiocyanate → 1-(3,5-Dichloro-phenyl)-3-[5-(1H-indol-2-yl)-2-methoxy-phenyl]-thiourea
https://huagongshe.com/reaction/25489
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 3,5-Dichlorophenyl isothiocyanate | HCID 138776 | — |
| 反応物 | 5-(1H-indol-2-yl)-2-methoxy-phenylamine | HCID 9900204 | — |
| 溶媒 | Ethyl Acetate | HCID 8857 | — |
| 生成物 | 1-(3,5-Dichloro-phenyl)-3-[5-(1H-indol-2-yl)-2-methoxy-phenyl]-thiourea | HCID 10138249 | — |
反応手順
The product from Example 1, Step B, 5-(1H-indol-2-yl)-2-methoxy-phenylamine (0.1765 g, 0.74 mmol) was mixed with 3,5-dichlorophenyl isothiocyanate (0.151 g, 0.74 mmol) in ethyl acetate (20 mL) and was heated briefly at 50° C. and then allowed to stand overnight at room temperature. The reaction mixture was concentrated to dryness, triturated with hexanes, and the insoluble material collected by filtration (0.169 g), mp 199-201° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US06858739B2 |
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| 出典データセット | uspto-grants-2005_02 |
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| ORD ID | ord-08c4b7bcaccd40cbb89fe90c35796575 |
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| 出典メモ | uspto-grants-2005_02 |
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