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HRID 25492作成日：2026年10月26日
3,5-Dichlorophenyl isothiocyanate → 1-(3,5-Dichloro-phenyl)-3-[5-(5,6-difluoro-1H-indol-2-yl)-2-methoxy-phenyl]-thiourea
https://huagongshe.com/reaction/25492
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 3,5-Dichlorophenyl isothiocyanate | HCID 138776 | — |
| 反応物 | 5-(5,6-difluoro1H-indol-2-yl)-2-methoxy-phenylamine | HCID 9943439 | — |
| 溶媒 | Ethyl Acetate | HCID 8857 | — |
| 生成物 | 1-(3,5-Dichloro-phenyl)-3-[5-(5,6-difluoro-1H-indol-2-yl)-2-methoxy-phenyl]-thiourea | HCID 10162695 | — |
反応手順
The product from Example 3, 5-(5,6-difluoro-1H-indol-2-yl)-2-methoxy-phenylamine, (0.137 g, 0.5 mmol) was mixed with 3,5-dichlorophenyl isothiocyanate (0.111 g, 0.54 mmol) in ethyl acetate (10 mL) and heated briefly to 50° C. and then allowed to stand overnight at room temperature. The reaction mixture was concentrated to dryness and triturated with hexanes/ethyl acetate, and the insoluble solid collected by filtration (0.214 g), mp 203-205° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US06858739B2 |
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| 出典データセット | uspto-grants-2005_02 |
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| ORD ID | ord-b9f40809b5674a1b9153c88959d84e0a |
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| 出典メモ | uspto-grants-2005_02 |
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