関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 1-Bromo-3,6-dioxaheptane | HCID 123532 | — |
| 反応物 | 2-Amino-5-methylthiazole | HCID 351770 | — |
| 生成物 | Ammonium Hydroxide | HCID 14923 | — |
| 生成物 | 3-(2-(2-methoxyethoxy)ethyl)-5-methylthiazol-2(3H)-imine | HCID 66858728 | — |
反応手順
A mixture of 2-amino-5-methylthiazole (1.5 g, 13.0 mmol) and 1-bromo-2-(2-methoxyethoxy)ethane (2.0 mL, 14.5 mmol) was warmed to 85° C. and stirred for 5 hours. The mixture was cooled to ambient temperature and the residue was purified via flash column chromatography (SiO2, 10% methanol in ethyl acetate then 9:1:01 CH2Cl2:methanol:NH4OH) to afford the title compound. MS (DCI/NH3) m/z 217 (M+H)+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07875639B2 |
|---|
| 出典データセット | uspto-grants-2011_01 |
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| ORD ID | ord-b76b92c8e42c49d5a61c8cd2d148337e |
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| 出典メモ | uspto-grants-2011_01 |
|---|
