関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | 2-Thiazolamine, 5-bromo- | HCID 43600 | — |
| 反応物 | 1-Adamantanecarbonyl chloride | HCID 98915 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | N-(5-bromo-1,3-thiazol-2-yl)adamantane-1-carboxamide | HCID 49760640 | — |
反応手順
A mixture of 5-bromothiazol-2-amine (3.0 g, 11.5 mmol), adamantane-1-carbonyl chloride (2.74 g, 13.8 mmol), triethylamine (3.2 mL, 23 mmol) and 4-di(methylamino)pyridine (1.1 g) in tetrahydrofuran (100 mL) was heated at 80° C. for 48 hours. The mixture was cooled to ambient temperature, concentrated, diluted with water and extracted with ethyl acetate. The organic extract was dried (Na2SO4), filtered and concentrated. Purification by flash chromatography (silica gel, 25% ethyl acetate/hexanes) afforded the title compound, MS (ESI) m/z 342 (M+H)+
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07875639B2 |
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| 出典データセット | uspto-grants-2011_01 |
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| ORD ID | ord-bd8e77ef11af43c8866b7ef80c1fb69c |
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| 出典メモ | uspto-grants-2011_01 |
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