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Sodium hydride → HCID 178495763、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium hydride | HCID 24758 | — |
| 反応物 | 2-Bromoethyl methyl ether | HCID 80972 | — |
| 反応物 | N-(5-bromo-1,3-thiazol-2-yl)adamantane-1-carboxamide | HCID 49760640 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | tetrahydrofuran N,N-dimethylformamide | HCID 21974620 | — |
| 生成物 | HCID 178495763 | HCID 178495763 | — |
反応手順
A solution of Example 131A (2.55 g, 7.43 mmol), 1-bromo-2-methoxyethane (0.77 mL, 8.15 mmol) and sodium hydride (60%) (386 mg, 9.66 mmol) in tetrahydrofuran/N,N-dimethylformamide (2:1) (60 mL) was heated at 75° C. for 12 hours. The mixture was cooled to ambient temperature, diluted with water, and extracted with dichloromethane. The organic extract was dried (Na2SO4), filtered and concentrated. Purification by chromatography (silica gel, 100% dichloromethane) afforded the title compound. MS (ESI) m/z 399 (M+H)+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07875639B2 |
| 出典データセット | uspto-grants-2011_01 |
| ORD ID | ord-3cf82a9863b64840a797ee1fa474185d |
| 出典メモ | uspto-grants-2011_01 |