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HRID 25513作成日：2026年10月23日
5-(1H-indol-2-yl)-2-methoxy-phenylamine → (4-{3-[5-(1h-Indol-2-yl)-2-methoxy-phenyl]-thioureido}-benzyl)-phosphonic acid diethyl ester
https://huagongshe.com/ja/reaction/25513
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 5-(1H-indol-2-yl)-2-methoxy-phenylamine | HCID 9900204 | — |
| 反応物 | Diethyl 4-isothiocyanatobenzylphosphonate | HCID 22568434 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | (4-{3-[5-(1h-Indol-2-yl)-2-methoxy-phenyl]-thioureido}-benzyl)-phosphonic acid diethyl ester | HCID 20760880 | — |
反応手順
The product from Example 1 (0.119 g, 0.5 mmol) and the product from Example 23, Step A (0.157 g, 0.54 mmol) were combined in tetrahydrofuran (8 mL), briefly heated to 50° C., and then allowed to stand for 6 hours at room temperature. The reaction mixture was concentrated to dryness and the residue triturated with hexanes/ethyl acetate. The product was collected by filtration (0.14 g), mp softening at 120° C., gradual decomposition.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US06858739B2 |
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| 出典データセット | uspto-grants-2005_02 |
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| ORD ID | ord-b6636ae04dcd49b496eab737963808b0 |
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| 出典メモ | uspto-grants-2005_02 |
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