2-Chlorocyclopentanone → 5,6-Dihydro-4H-cyclopenta[d]thiazol-2-amine hydrochloride

HRID 255150

反応式

HRID 255150 の反応式
[Cl:1][CH:2]1[CH2:6][CH2:5][CH2:4][C:3]1=O.[NH2:8][C:9]([NH2:11])=[S:10]>>[ClH:1].[S:10]1[C:3]2[CH2:4][CH2:5][CH2:6][C:2]=2[N:8]=[C:9]1[NH2:11]

参加物

3

反応物 2

HCID 127512-ChlorocyclopentanoneHCID 2723790Thiourea

生成物 1

HCID 162532465,6-Dihydro-4H-cyclopenta[d]thiazol-2-amine hydrochloride

反応条件

温度
80 °C

実験手順

A mixture of 2-chlorocyclopentanone (5.00 g, 39.5 mmol) and thiourea (3.00 g, 39.5 mmol) was heated at 80° C. for 3-4 minutes. After cooling to room temperature, the mixture was triturated with ethanol and the solid was collected by filtration to afford the title compound. MS (ESI) m/z 141 (M+H)+.

後処理

  1. temperatureAfter cooling to room temperature
  2. customthe mixture was triturated with ethanol
  3. filtrationthe solid was collected by filtration

出典と根拠

ORDレコード
ord-68e40f2e96ba47dab34674e11ed228d7
出典データセット
uspto-grants-2011_01
特許番号
US07875639B2

関連ノート

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