関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | N,N'-Dimethylurea | HCID 7293 | — |
| 反応物 | 4-Fluoroanthranilic acid | HCID 2724967 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 2-amino-4-fluoro-N-methylbenzamide | HCID 56951661 | — |
反応手順
A mixture of 2-amino 4-fluoro benzoic acid (2.5 g, 16.13 mmol) and 1,3 dimethyl urea (5.85 g, 66.5 mmol) was heated at 150° C. for 24 hours. The reaction was diluted with water, filtered and extracted twice with ethyl acetate. The organic extracts were dried over magnesium sulfate and concentrated at reduced pressure. Chromatography on silica gel with ethyl acetate in hexanes (0-50%) gave the title compound as a waxy solid (670 mg, 25%)
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07875715B2 |
|---|
| 出典データセット | uspto-grants-2011_01 |
|---|
| ORD ID | ord-98808f368c2d4988b537d19cf74e01c2 |
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| 出典メモ | uspto-grants-2011_01 |
|---|
