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Citric Acid → Benzyl 2-methylaziridine-1-carboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Citric Acid | HCID 311 | — |
| 反応物 | 2-Methylaziridine | HCID 6377 | — |
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | Benzyl chloroformate | HCID 10387 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | Benzyl 2-methylaziridine-1-carboxylate | HCID 21895246 | — |
反応手順
2-Methyl aziridine is dissolved in CH2Cl2 and triethylamine under argon at 0° C. Benzylchloroformate is added and the contents of the flask are at room temperature overnight. The mixture is poured into 10% citric acid and is extracted with CHCl3. The organic layer is washed with dilute aqueous NaHCO3 and dried over MgSO4. The solution is evaporated to yield N-Cbz-2-methyl aziridine.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04698231 |
| 出典データセット | uspto-grants-1987_10 |
| ORD ID | ord-1a4e7089217245829b297700e2f626b8 |
| 出典メモ | uspto-grants-1987_10 |