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Water → 1-(2-Amino-2-methylpropoxy)-2,2,5,5-tetramethylcyclopentane
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Potassium Hydroxide | HCID 14797 | — |
| 反応物 | N-Boc-1-(2-amino-2-methylpropoxy)-2,2,5,5-tetramethyl cyclopentane | HCID 20165736 | — |
| 溶媒 | Trifluoroacetic acid | HCID 6422 | — |
| 生成物 | 1-(2-Amino-2-methylpropoxy)-2,2,5,5-tetramethylcyclopentane | HCID 20165755 | — |
反応手順
N-Boc-1-(2-amino-2-methylpropoxy)-2,2,5,5-tetramethyl cyclopentane is dissolved in trifluoroacetic acid and stirred overnight. The solution is poured into water and neutralized with 20% aqueous KOH. The mixture is extracted with ethyl acetate, dried over MgSO4, filtered and evaporated to give 1-(2-amino-2-methylpropoxy)-2,2,5,5-tetramethylcyclopentane.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04698231 |
| 出典データセット | uspto-grants-1987_10 |
| ORD ID | ord-1a1f9a151e464812b3c202bdce184c17 |
| 出典メモ | uspto-grants-1987_10 |