Hydrogen Peroxide → HCID 20183620、化合物

反応式

[CH3:1][N:2]1[C:14]2[C:13]3[CH:12]=[C:11]([F:15])[CH:10]=[CH:9][C:8]=3[N:7]=[C:6]([CH3:16])[C:5]=2[N:4]=[CH:3]1.[OH:17]O>>[CH3:1][N:2]1[C:14]2[C:13]3[CH:12]=[C:11]([F:15])[CH:10]=[CH:9][C:8]=3[N+:7]([O-:17])=[C:6]([CH3:16])[C:5]=2[N:4]=[CH:3]1

参加物

反応物 2

HCID 784Hydrogen Peroxide

HCID 13958443HCID 13958443、化合物

生成物 1

HCID 20183620HCID 20183620、化合物

実験手順

Using the method of Example 74, 1,4-dimethyl-8-fluoro-1H-imidazo[4,5-c]quinoline (from Example 140) was reacted with hydrogen peroxide to provide 1,4-dimethyl-8-fluoro-1H-imidazo[4,5-c]quinolin-5-oxide, m.p. 245°-248° C. Analysis: Calculated for C12H10FN3O: %C, 62.3; %H, 4.4; %N, 18.2; Found: %C, 62.7; %H, 4.3; %N, 18.3.

出典と根拠

ORDレコード: ord-37a7e04018a94545a5b60fbcfe7e736c
出典データセット: uspto-grants-1987_10
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US04698348

反応ノート

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