Pyridinium chloride → 3-(4-Phenyl-1,2,3,6-tetrahydro-1-pyridylmethyl)-6-hydroxy-1,2,3,4-tetrahydrocarbazole

HRID 255577

反応式

HRID 255577 の反応式
Cl.[C:2]1([C:8]2[CH2:9][CH2:10][N:11]([CH2:14][CH:15]3[CH2:27][C:26]4[C:25]5[C:20](=[CH:21][CH:22]=[C:23]([O:28]C)[CH:24]=5)[NH:19][C:18]=4[CH2:17][CH2:16]3)[CH2:12][CH:13]=2)[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl.N1C=CC=CC=1>C1(C)C=CC=CC=1.C(N(CC)CC)C>[C:2]1([C:8]2[CH2:13][CH2:12][N:11]([CH2:14][CH:15]3[CH2:27][C:26]4[C:25]5[C:20](=[CH:21][CH:22]=[C:23]([OH:28])[CH:24]=5)[NH:19][C:18]=4[CH2:17][CH2:16]3)[CH2:10][CH:9]=2)[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

4

反応物 2

HCID 10176127Pyridinium chlorideHCID 201837593-(4-Phenyl-1,2,3,6-tetrahydro-1-pyridylmethyl)-6-methoxy-1,2,3,4-tetrahydrocarbazole hydrochloride

生成物 1

HCID 201836973-(4-Phenyl-1,2,3,6-tetrahydro-1-pyridylmethyl)-6-hydroxy-1,2,3,4-tetrahydrocarbazole

試薬・触媒・溶媒 1

HCID 22504574Toluene triethylamine溶媒

実験手順

A mixture of 4.19 g of 3-(4-phenyl-1,2,3,6-tetrahydro-1-pyridylmethyl)-6-methoxy-1,2,3,4-tetrahydrocarbazole hydrochloride and 3.5 g of pyridine hydrochloride is stirred at 160° for 3 hours. After the usual work-up, 3-(4-phenyl-1,2,3,6-tetrahydro-1-pyridylmethyl)-6-hydroxy-1,2,3,4-tetrahydrocarbazole, Rf 0.2 (toluene/triethylamine 9:1), is obtained.

出典と根拠

ORDレコード
ord-f5ff682afab84db69d5075a4d35e2c49
出典データセット
uspto-grants-1987_10
特許番号
US04698351

関連ノート

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