Acetic Acid → Diethyl 4-oxo-4H-quinolizine-1,3-dicarboxylate

HRID 255593

反応式

HRID 255593 の反応式
[O-]CC.[Na+].[N:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[CH2:11][C:12]([O:14][CH2:15][CH3:16])=[O:13].C([O:19][CH:20]=[C:21]([C:27](OCC)=O)[C:22]([O:24][CH2:25][CH3:26])=[O:23])C.C(O)(=O)C>C(O)C>[CH2:15]([O:14][C:12]([C:11]1[CH:27]=[C:21]([C:22]([O:24][CH2:25][CH3:26])=[O:23])[C:20](=[O:19])[N:5]2[C:6]=1[CH:7]=[CH:8][CH:9]=[CH:10]2)=[O:13])[CH3:16]

参加物

6

反応物 4

HCID 176Acetic AcidHCID 6871Diethyl (ethoxymethylene)malonateHCID 75960Ethyl 2-pyridylacetateHCID 2723922Sodium ethoxide

生成物 1

HCID 262620Diethyl 4-oxo-4H-quinolizine-1,3-dicarboxylate

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To a solution of sodium ethoxide (sodium, 151 mg) in ethanol (20 ml) was added ethyl pyrid-2-ylacetate (1 ml) at room temperature and the mixture was stirred for 1 hour at the same temperature. To the mixture was added diethyl ethoxymethylenemalonate (1.33 ml) at room temperature and the mixture was stirred at room temperature overnight. To the mixture was added acetic acid (0.75 ml) at room temperature and the precipitate was filtered and washed with water to give 1,3-diethoxycarbonyl-4H-quinolizin-4-one (896 mg).

後処理

  1. stirringthe mixture was stirred at room temperature overnight
  2. filtrationthe precipitate was filtered
  3. washwashed with water

出典と根拠

ORDレコード
ord-1f75550736664cc0bc9eca4bd6b837ec
出典データセット
uspto-grants-1987_10
特許番号
US04698349

関連ノート

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