Phosphorus oxychloride → HCID 20184101、化合物

反応式

[CH3:1][N:2]([CH3:31])[CH2:3][CH2:4][CH2:5][N:6]([C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1)[C:7]1[C:12]([NH:13][C:14](=O)[C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=2[N+:21]([O-:23])=[O:22])=[CH:11][CH:10]=[CH:9][N:8]=1.P(Cl)(Cl)([Cl:34])=O>>[ClH:34].[CH3:1][N:2]([CH3:31])[CH2:3][CH2:4][CH2:5][N:6]1[C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=2[C:14]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=2[N+:21]([O-:23])=[O:22])=[N:13][C:12]2[CH:11]=[CH:10][CH:9]=[N:8][C:7]1=2

参加物

反応物 2

HCID 24813Phosphorus oxychloride

HCID 13986493HCID 13986493、化合物

生成物 1

HCID 20184101HCID 20184101、化合物

実験手順

Following the procedure of Example 51, N-[2-[[3-(dimethylamino)propyl]phenylamino]-3-pyridinyl]-2-nitrobenzamide was cyclized to the free base of title compound with phosphorus oxychloride and thereafter converted to the hydrochloride by reacting with ethereal hydrogen chloride. Recrystallization from isopropyl alcohol, the yellow solid melted at 239°240° C.

出典と根拠

ORDレコード: ord-050b83e8ccc645c68cc89a2353c38786
出典データセット: uspto-grants-1987_10
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US04698430

反応ノート

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