Phosphorus oxychloride → 7-[2-(2-Formamidothiazol-4-yl)-2-(2,2,2-trifluoroethyoxyimino)acetamido]-3-(1,3,4-thiadiazol-2-yl)thiomethyl-3-cephem-4-carboxylic acid

反応式

C[N+](C)=CCl.[Cl-].P(Cl)(Cl)(Cl)=O.[CH:12]([NH:14][C:15]1[S:16][CH:17]=[C:18]([C:20](=[N:24][O:25][CH2:26][C:27]([F:30])([F:29])[F:28])[C:21]([OH:23])=O)[N:19]=1)=[O:13].[NH2:31][CH:32]1[C:49](=[O:50])[N:34]2[C:35]([C:46]([OH:48])=[O:47])=[C:36]([CH2:39][S:40][C:41]3[S:42][CH:43]=[N:44][N:45]=3)[CH2:37][S:38][C@H:33]12.C[Si](CC(N)=O)(C)C>C(OCC)(=O)C.O.CN(C)C=O>[CH:12]([NH:14][C:15]1[S:16][CH:17]=[C:18]([C:20](=[N:24][O:25][CH2:26][C:27]([F:30])([F:29])[F:28])[C:21]([NH:31][CH:32]2[C:49](=[O:50])[N:34]3[C:35]([C:46]([OH:48])=[O:47])=[C:36]([CH2:39][S:40][C:41]4[S:42][CH:43]=[N:44][N:45]=4)[CH2:37][S:38][C@H:33]23)=[O:23])[N:19]=1)=[O:13]