化工社化工社 化学情報印刷レポート · 研究参考用
Methyl iodide → 2,2-Dimethyl-4-methoxyindanone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methyl iodide | HCID 6328 | — |
| 反応物 | Tetrahydrofuran | HCID 8028 | — |
| 反応物 | Sodium hydride | HCID 24758 | — |
| 反応物 | 4-Hydroxy-1-indanone | HCID 590547 | — |
| 生成物 | 2,2-Dimethyl-4-methoxyindanone | HCID 13692943 | — |
反応手順
4-Hydroxy-indanone (25 g) is added portionwise to a stirred suspension of sodium hydride (40.1 g, 60% in mineral oil) and methyl iodide (62.4 g) in anhydrous THF (990 ml) under nitrogen and the mixture is stirred at RT overnight. The reaction mixture is quenched with H2O, washed with diethyl ether and the etheral layer is washed with 10% aq. NaHSO3 and H2O, dried, filtered, and evaporated. The residue is chromatographed (silica gel; eluent=hexane/EtOAC) affording the desired product as a solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04699906 |
| 出典データセット | uspto-grants-1987_10 |
| ORD ID | ord-bb2a6ed572d8406ab7a288aafce2c017 |
| 出典メモ | uspto-grants-1987_10 |