N-Bromosuccinamide → HCID 13958751、化合物
反応式
[C:1]1(=[O:16])[N:5]([CH2:6]/[C:7](/[CH3:10])=[CH:8]/[F:9])[C:4](=[O:11])[C:3]2=[CH:12][CH:13]=[CH:14][CH:15]=[C:2]12.[Br:17]NC(=O)CCC(N)=O>C(Cl)(Cl)(Cl)Cl>[F:9]/[CH:8]=[C:7](\[CH2:10][Br:17])/[CH2:6][N:5]1[C:4](=[O:11])[C:3]2=[CH:12][CH:13]=[CH:14][CH:15]=[C:2]2[C:1]1=[O:16]参加物
4
実験手順
A mixture of 1-phthalimido-2-methyl-3-fluoro-2-propene (prepared in Step E) (2.09 g) and N-bromosuccinamide (1.78 g) in carbon tetrachloride (100 ml) was refluxed for 45 min. The cooled mixture is filtered and the filtrate is washed with water, dried and evaporated to leave an almost colorless oil. Chromatography (silica; 20% ether in light petroleum) followed by recrystallization of the major fractions from EtOAc/light petroleum gives:
後処理
- temperaturewas refluxed for 45 min
- filtrationThe cooled mixture is filtered
- washthe filtrate is washed with water
- customdried
- customevaporated
- customto leave an almost colorless oil
- customChromatography (silica; 20% ether in light petroleum) followed by recrystallization of the major fractions from EtOAc/light petroleum
- customgives
出典と根拠
- ORDレコード
- ord-6bd9c27fd4cc44f7aee7ac57db43ae15
- 出典データセット
- uspto-grants-1987_10
- 特許番号
- US04699928
反応ノート
読み込み中…