Methylhydrazine → t-Butyl alpha-(6-amino-5-oxo-2-phenylperhydro-1,4-thiazepin-4-yl)acetate
反応式
[O:1]=[C:2]1[CH:8]([N:9]2C(=O)C3=CC=CC=C3C2=O)[CH2:7][S:6][CH:5]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[CH2:4][N:3]1[CH2:26][C:27]([O:29][C:30]([CH3:33])([CH3:32])[CH3:31])=[O:28].CNN>>[NH2:9][CH:8]1[CH2:7][S:6][CH:5]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[CH2:4][N:3]([CH2:26][C:27]([O:29][C:30]([CH3:32])([CH3:31])[CH3:33])=[O:28])[C:2]1=[O:1]参加物
3
実験手順
0.4 g of diastereomer B of t-butyl α-[5-oxo-2-phenyl-6-phthalimidoperhydro-1,4-thiazepin-4-yl]acetate [prepared as described in step (f) above] was subjected to dephthaloylization with methylhydrazine in the same manner as described in Example 1(g), to give 0.22 g of the title compound as an amorphous solid.
出典と根拠
- ORDレコード
- ord-b963a63bc2de47c0a5d42f61b1530a0f
- 出典データセット
- uspto-grants-1987_10
- 特許番号
- US04699905
反応ノート
読み込み中…