Phosphorus pentachloride → 2-t-Butoxycarbonylamino-1-chloro-1-(2-thienyl)ethane

反応式

[C:1]([O:5][C:6]([NH:8][CH2:9][CH:10]([C:12]1[S:13][CH:14]=[CH:15][CH:16]=1)O)=[O:7])([CH3:4])([CH3:3])[CH3:2].P(Cl)(Cl)(Cl)(Cl)[Cl:18]>>[C:1]([O:5][C:6]([NH:8][CH2:9][CH:10]([Cl:18])[C:12]1[S:13][CH:14]=[CH:15][CH:16]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

参加物

反応物 2

HCID 24819Phosphorus pentachloride

HCID 13854069Carbamic acid, [2-hydroxy-2-(2-thienyl)ethyl]-, 1,1-dimethylethyl ester

生成物 1

HCID 138540702-t-Butoxycarbonylamino-1-chloro-1-(2-thienyl)ethane

実験手順

Following the procedure described in Example 42(b), 15 g of 2-t-butoxycarbonylamino-1-(2-thienyl)ethanol were chlorinated using phosphorus pentachloride to afford 13.6 g of the title product as crystals melting at 40°-43° C. This substance was used for next step without purification because it was decomposed by silica gel column chromatography.

出典と根拠

ORDレコード: ord-d545e62841c642bca6e98f9aa3aecc6d
出典データセット: uspto-grants-1987_10
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US04699905

反応ノート

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