関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Dimethylformamide | HCID 6228 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | Phosphorus oxychloride | HCID 24813 | — |
| 反応物 | 2-(4-Methoxyphenyl)indolizine | HCID 346949 | — |
| 生成物 | 2-(4-Methoxyphenyl)indolizine-3-carbaldehyde | HCID 3800656 | — |
反応手順
A slurry of 20 g of 2-(4-methoxy phenyl) indolizine in 35 ml of DMF was added to a solution of 10 ml of phosphorus oxychloride in 30 ml of DMF at 10-20° C. After the reaction solution was stirred at 40° for 40 min., it was added to 200 g of ice. 120 g of 25 percent sodium hydroxide solution was added and the resulting mixture was heated to 55° C., cooled, and filtered. The air-dried product weighed 23 g.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US04701398 |
|---|
| 出典データセット | uspto-grants-1987_10 |
|---|
| ORD ID | ord-0eef2b4bac6647ffa1de02d2a5220f89 |
|---|
| 出典メモ | uspto-grants-1987_10 |
|---|
