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Diethyl 5-hydantoylphosphonate → N-Cyclohexyl-1-[3-[(2,4-dioxoimidazolidin-5-ylidene)methyl]-4-nitrophenyl]-N-methyl-3-piperidinecarboxamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Diethyl 5-hydantoylphosphonate | HCID 3516088 | — |
| 反応物 | 2-nitro-5-[3-(N-methyl-N-cyclohexylcarbamoyl)-1-piperidinyl]benzaldehyde | HCID 20164152 | — |
| 生成物 | N-Cyclohexyl-1-[3-[(2,4-dioxoimidazolidin-5-ylidene)methyl]-4-nitrophenyl]-N-methyl-3-piperidinecarboxamide | HCID 53710199 | — |
反応手順
Prepared from diethyl 2,4-dioxoimidazolidine-5-phosphonate and 2-nitro-5-[3-(N-methyl-N-cyclohexylcarbamoyl)-1-piperidinyl]benzaldehyde analogous to the procedure of Example (2-1), m.p. 153°-162° C., crystallized from MeOH-H2O.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04701459 |
| 出典データセット | uspto-grants-1987_10 |
| ORD ID | ord-57ba92b17d924b00b54ea524b9726496 |
| 出典メモ | uspto-grants-1987_10 |