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p-Toluenesulfonic acid → N-(3-formylphenyl)acetamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | p-Toluenesulfonic acid | HCID 6101 | — |
| 反応物 | N-[3-(1,3-dioxolan-2-yl)phenyl]acetamide | HCID 13987600 | — |
| 溶媒 | Acetone | HCID 180 | — |
| 生成物 | N-(3-formylphenyl)acetamide | HCID 256849 | 100.6% |
反応手順
A solution of N-[3-(1,3-dioxolan-2-yl)phenyl]acetamide (50.0 g, 0.24 mole) and p-toluenesulfonic acid (1.0 g) in acetone (750 mL) was stirred at room temperature for 72 hours. The solution was filtered through a pad of neutral alumina and concentrated in vacuo to afford N-(3-formylphenyl)acetamide (39.4 g, 100%), mp 68°-70° C., used without further purification below.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04701459 |
| 出典データセット | uspto-grants-1987_10 |
| ORD ID | ord-2a1da0083d5e4beb8dfc71136665e958 |
| 出典メモ | uspto-grants-1987_10 |