HCID 178474351、化合物 → HCID 178507948、化合物
反応式
C([NH:4][C:5]1[C:9]2[CH:10]=[CH:11][CH:12]=[CH:13][C:8]=2[O:7][C:6]=1[C:14]([NH:16][C:17]1[NH:21][N:20]=[N:19][N:18]=1)=[O:15])(=O)C>C(O)C>[NH2:4][C:5]1[C:9]2[CH:10]=[CH:11][CH:12]=[CH:13][C:8]=2[O:7][C:6]=1[C:14]([NH:16][C:17]1[NH:21][N:20]=[N:19][N:18]=1)=[O:15]参加物
3
実験手順
A mixture of 5.3 g (0.019 mole) of 3-(acetylamino)N-1H-tetrazol-5-yl-2-benzofurancarboxamide in 50 ml of ethanol plus 50 ml of concentrated (12.0 M) hydrochloric acid is stirred at reflux for two hours. The reaction mixture is cooled in ice to precipitate 3-amino-N-1H-tetrazol-5-yl-2-benzofurancarboxamide. The precipitate is filtered, washed with 50% aqueous ethanol, and recrystallized from aqueous 2-methoxyethanol to yield 2.4 g (53% yield) of the analytically pure 3-amino-N-1H-tetrazol-5-yl-2-benzofurancarboxamide, mp 275° C.-dec.
後処理
- concentrationof concentrated (12.0 M) hydrochloric acid
- temperatureat reflux for two hours
- temperature