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1-[2-(Benzyloxycarbonylamino)propanoyl]-2,2-dimethyl-4-imidazolidinone → 1-(2-Aminopropanoyl)-2,2-dimethyl-4-imidazolidinone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-[2-(Benzyloxycarbonylamino)propanoyl]-2,2-dimethyl-4-imidazolidinone | HCID 20163715 | — |
| 反応物 | HCID 178418361 | HCID 178418361 | — |
| 触媒 | Palladium | HCID 23938 | — |
| 生成物 | 1-(2-Aminopropanoyl)-2,2-dimethyl-4-imidazolidinone | HCID 20163710 | — |
反応手順
An ethanolic solution of 1-[2-(benzyloxycarbonylamino)propanoyl]-2,2-dimethyl-4-imidazolidinone (4.9 g) containing 1 g of 5% palladium on charcoal was stirred at room temperature while hydrogen was bubbled into the solution for 1 hour. Removal of the catalyst, evaporation of the solvent, and trituration of the residue with ethyl acetate afforded the title compound as a white powder m.p. 156° C. (decomp).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04703054 |
| 出典データセット | uspto-grants-1987_10 |
| ORD ID | ord-a0051da0bff6437eb70d71b84b48fe98 |
| 出典メモ | uspto-grants-1987_10 |