Ammonia → 2,2-Dimethyl-5-oxo-1-imidazolidineacetamide
反応式
[CH3:1][C:2]1([CH3:14])[NH:6][CH2:5][C:4](=[O:7])[N:3]1[CH2:8][C:9](OCC)=[O:10].[NH3:15]>CO>[CH3:1][C:2]1([CH3:14])[NH:6][CH2:5][C:4](=[O:7])[N:3]1[CH2:8][C:9]([NH2:15])=[O:10]参加物
4
実験手順
An ice-cold solution of ethyl 2,2-dimethyl-5-oxo-1-imidazolidineacetate (2 g) in methanol (150 ml) was saturated with gaseous ammonia). The solution was stirred at room temperature for 36 hours. After evaporation the residue was chromatographed on a silica gel column, eluting with dichloromethane/methanol 6:4. The selected fractions were collected, evaporated and the residue was crystallized from ethanol, to give 2,2-dimethyl-5-oxo-1-imidazolidineacetamide (1 g) as a white powder, m.p. 144°-146°.
後処理
- customAfter evaporation the residue
- customwas chromatographed on a silica gel column
- washeluting with dichloromethane/methanol 6:4
- customThe selected fractions were collected
- customevaporated
- customthe residue was crystallized from ethanol
出典と根拠
- ORDレコード
- ord-1e1e62095608494abbf900d03ff8874b
- 出典データセット
- uspto-grants-1987_10
- 特許番号
- US04703054
反応ノート
読み込み中…